A Gov. Chris Christie 2016 presidential run would set off many hot-button debates, including the issue of legalizing marijuana.

Medical Marijuana (David McNew, Getty Images)

If Christie runs and wins, he could deal a major blow to efforts to legalize the drug.

This week, he reaffirmed his position opposing any idea of making pot legal in New Jersey, and also reiterated that he is not really a fan of the state's medical marijuana program.

Christie vowed to keep medical marijuana as a medical-based program and not stray towards the side as 'a front for legalization.'

Many states, including Colorado, Oregon, and Washington, have recently legalized pot without government intervention, while it remains illegal on the national level.

Christie said if he were president, he would enforce the federal law, which lists pot as an illegal drug.